CME Grand Rounds Suzanne E. Lapi, PhD

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CME Grand Rounds – From Isotopes to Images: Applications of Radiometals for Nuclear Medicine

Suzanne E. Lapi, PhD

Professor of Radiology and Chemistry; Vice Chair of Research, Radiology; Director, UAB Cyclotron Facility, University of Alabama at Birmingham

ABSTRACT

Molecular imaging is a powerful technique that can be applied to basic, translational, and clinical research as well as to routine patient care. In particular, Positron Emission Tomography (PET)  allows for spatial localization and quantification of biological processes such as metabolism, enzyme activity, cell proliferation, receptor density and cellular transport that are not readily assessed with conventional anatomic imaging techniques. Using the UAB TR24 cyclotron, our group has focused on the production and purification of radioactive isotopes to expand the toolbox of nuclear imaging agents. These have included transition metals such as ⁵²Mn, ⁶⁴Cu, ⁵⁵Co, ⁸⁹Zr, ^43,47Sc and ⁴⁵Ti.  Additional research has developed chemistry to incorporate these radioisotopes into new imaging radiopharmaceuticals for preclinical or clinical research for many diseases.  For example, our group has focused on the use of ⁸⁹Zr radiolabeled antibodies for imaging of cell surface receptor expression (HER2, EGFR) in preclinical models and in a clinical trial of metastatic breast cancer patients.  Additionally, we have been developing strategies for paired imaging and therapeutic agents.